SUNDAY, September 7^th

Registration

17:00 –  20:00

Registration

Ice Breaker Party

MONDAY, September 8^th

9:00 –  9:30

Vice President of the University:

Prof. Dr. Preuß

Organizers: Decker/Markl,

Welcome

9:30 –  10:00

L1 Benedetto Salvato (Italy)

Ghiretti lecture

Session S1: New structures based on X-ray and EM [van Bruggen]

10:30 –  11:00

L2 Ulrich Meissner (Germany)

3D reconstruction of the quaternary structure of invertebrate hemocyanins and hemolymph proteins from cryo-electron micrographs

11:00 –  11:20

L3 Hermann Hartmann (Germany)

Small-angle scattering techniques for analysing conformational transitions in hemocyanins

11:20 –  11:40

L4 William Royer (USA)

Crystal structures of Lumbricus erythrocruorin and Riftia C1 (400kDa) hemoglobin

Break

12:10 – 12:30

L5 Franck Zal (France)

Comparative ESI-MS study of ~2.2 MDa native hemocyanins from deep-sea and shore crabs : from oligomerization to the biotope of the crabs

12:30 – 12:50

L6 Mariano Beltramini (Italy)

Structural role of the copper ions in the dinuclear active site of Carcinus aestuarii hemocyanin

Lunch

Session S2: Physiology and adaptation [Paul, Toulmond, Morris]

14:30 –  14:55

L7  Steve Morris  (UK)

Unique functions of land crab hemocyanin

14:55 –  15:20

L8 Hans-Otto Pörtner (Germany)

Maximization of hemocyanin performance in marine invertebrate athletes

15:20 –  15:45

L9 Roy Weber (Denmark)

“Novel” factors that regulate oxygene binding in vertebrate hemoglobins

15:45 –  16:10

L10 Didier Jollivet (France)

Evolution of hemoglobins in deep-sea hydrothermal vent polynoids

Break

16:30 –  16:55

L11 Ralph Pirow (Germany)

The physiological performance of hemoglobin in the planktonic crustacean Daphnia magna

16:55 –  17:15

L12 Bettina Zeis (Germany)

Molecular adaptation of Daphnia magna hemoglobin

17:15 –  17:40

L13 Xavier Bailly (France)

Detection of positive Darwinian selection events from globin molecular evolution suggests the loss of hemoglobin sulfide binding function in annelids from sulfide-free environments.

17:40 – 18:00

L14 Thomas Gorr (USA)

Oxygen dependent expression of globin genes in Daphnia and Drosophila - Role of HIF

Evening

19:30

Special event

TUESDAY, September 9^th

Session S3: Globins: New functions, structure and evolution [Hankeln, Burmester]

 9:00 –  9:30

L15  Jonathan Wittenberg (USA)

The function of intracellular globins

 9:30 –  9:50

L16  Michel Guertin (USA)

Truncated hemoglobins from Mycobacterium tuberculosis

 9:50 –  10:10

L17  Martino Bolognesi (Italy)

Structure and conundrums in the truncated Hb family

10:10 –  10:40

L18  Sylvia Dewilde (Belgium)

Functional aspects of neuroglobin and cytoglobin

10:40 –  11:00

L19  Thomas Hankeln (Germany)

Neuroglobin and cytoglobin: recent developments and prospects

Break

11:30 –  12:00

L20  Axel Gödecke (Germany)

Myoglobin in O₂ transport and NO detoxification

12:00 –  12:20

L21  Michael Marden (France)

Ligand binding kinetics of neuroglobin and cytoglobin

12:20 –  12:40   

L22  Mark Hargrove (USA)

Hexacoordinate hemoglobins in plants and animals

12:40 –  13:00

L23 Gerd N. La Mar (USA)

Solution 1H NMR characterization of structural and dynamic properties of mouse neuroglobin

Lunch

14:30 –  14:50

L24 Alessandra Pesce (Italy)

The Human brain hexacoordinated neuroglobin three-dimensional structure

14:50 –  15:10

L25 Karin Nienhaus (Germany)

Ligand dynamics and binding in heme proteins

15:10 – 15:30

L26 Juliette Lecombe (USA)

Structural properties of cyanobacterial hemoglobins: The unusual heme-protein cross-link of Synechocystis sp. PCC 6803 and Synechococcus sp. PCC 7002 Hb

Break

Session S4: Hemoglobin during ontogenesis [Pelster, Weber]

16:00 –  16:30

L27 Tom Brittain (New Zealand)

The Structure and function of the human embryonic hemoglobins.

16:30 –  16:50

L28 Bernd Pelster (Austria)

New microscopical insights in the Root effect

16:50 –  17:10

L29 Rosi Baumann (Germany)

Developmental regulation of allosteric effector pattern of avian embryonic hemoglobin

17:10 – 17:40

L30 Guido Di Prisco (Italy)

On the structure/function and phylogeny of hemoglobins of polar fishes

Evening

18:00 –  open end

Poster Session

Wine, Sausage, Brezeln, Snacks
„Mainz’ Lifestyle“

WEDNESDAY, September 10^th

Session S5: Structure and activation of phenoloxidase and hemocyanin [Söderhäll, Sugumaran]

 9:00 –  9:30

L31 Bernd Krebs (Germany)

Catechol oxidase and its relation to hemocyanin and tyrosinase

 9:30 – 10:00

L32 M. Sugumaran (USA)

Function and properties of insect phenoloxidases

10:00 –  10:30

L33 Bok Luel Lee (Korea)

Pro-phenoloxidase and its activation in an insect

Break

Session S6: Physiology of phenoloxidase and activated hemocyanin; Innate Immunity

11:00 –  11:30

L34 Kenneth Söderhäll (Sweden)

Innate immunity in crustaceans, the propo-system and hematopoiesis

11:30 –  11:50  

L35 Werner E.G. Müller (Germany)

Oxygen as morphogenic factor in sponges: Expression of an Iroquois homeobox and a tyrosinase gene in the sponge Suberites domuncula

11:50 –  12:10

L36 Kohsuke Adachi (Japan)

Enzymatic characterization of hemocyanin in crustacean

12:10 –  12:40

L37 Elmar Jaenicke (Germany)

Functional changes in the family of type 3 copper proteins during evolution

Lunch

Session S7: Medical implications and carbohydrates [Zal, Bonaventura]

14:30 – 15:00

L38 Joe Bonaventura (USA)

Interactions of vertebrate and invertebrate hemoglobins with nitric oxide: Relevance to blood substitutes

15:00 – 15:20

L39 John Harrington  (USA)

Lumbricus hemoglobin, a dodecameric acellular hemoglobin: Implications for the design of therapeutic oxygen carriers

15:20 – 15:40

L40 Thomas Wölfel (Germany)

Tyrosinase in cancer research

15:40 – 16:00

L41 Constant Gielens (Belgium)

Glycosylation sites of hemocyanins of Helix pomatia and Sepia officinalis

Break

16:20 – 16:40

L42 Pavlina Dolashka-Angelova (Bulgaria)

Carbohydrate moieties of molluscan Rapana venosa hemocyanin

16:40 – 17:00

L43 Rudolf Geyer (Germany)

Characterization of N-linked carbohydrates from keyhole limpet hemocyanin (KLH)

17:00 – 17:20

L44 Günther Stoll (Germany)

KLH as a therapeutical tool in oncology: Biological response modifier and tumor vaccine carrier

Poster Session & Events

open end

Sightseeing of Mainz
or
special event

Possibility of guided tours to the highlights of Mainz: Gutenberg Museum, Cathedral, Chagall windows, wine bars etc.

THURSDAY, September 11^th

Session S8: Cooperativity and Allostery [van Holde]

9:00 –  9:30

L45 Gary Ackers (USA)

Mechanistic roles of intra-dimer versus cross-dimer ligation in human hemoglobin cooperativity

9:30 –  9:50

L46 James Knapp (USA)

Time-resolved and ultra-high resolution crystallographic analysis of the cooperative ligand-binding pathway of Scapharca HbI

9:50 – 10:10

L47 Nadja Hellmannn (Germany)

Urate as effector for crustacean hemocyanins

10:10 – 10:30

L48 Christian Betzel  (Germany)

The structure of a functional unit from the wall of a gastropod hemocyanin offers a possible mechanism for cooperativity

10:30 – 10:50

L49 Wolfgang Erker (Germany)

Toward oxygen binding curves of single respiratory proteins

Break  

Session S9: Hemocyanins in evolution and during ontogenesis [Beltramini, Gielens]

11:20 – 11:50

L50 Nora Terwilliger (USA)

Hemocyanins during ontogenesis

11:50 – 12:10

L51 Marius Brouwer (USA)

Control of hemocyanin biosynthesis in the blue crab Callinectes sapidus

12:10 – 12:30

L52 Knut Beuerlein (Germany)

Hemocyanin biosynthesis in embryonic Sepia

Lunch

14:00 – 14:20

L53 Bernd Lieb (Germany)

Molluscan evolution traced by hemocyanin sequences

14:20 – 14:40

L54 Thorsten Burmester (Germany)

Evolution and diversity of the arthropod hemocyanin superfamily

Break

Session S10: Extracellular hemoglobins [Terwilliger]

15:00 –  15:30

L55 Serge Vinogradov (USA)

Hexagonal bilayer hemoglobins and chlorocruorins - a perspective

15:30 –  15:50

L56 Ezra Daniel (Israel)

On the molecular mass of Lumbricus erythrocruorin

Break 

16:00 – 

Podium discussion

The future of this meeting

Evening

18:30 –  23:30

Conference-Dinner

FRIDAY, September 12^th

Session S11: Active Sites [Casella, Bubacco]

9:00 –  9:30

L57 Joel Friedmann (USA)

Conformational dynamics and reactivity in truncated hemoglobins

9:30 –  9:50

L58 Martino Bolognesi (Italy)

The heme cavity: structural factors in O₂ binding

9:50 – 10:20

L59 Andreas Zuberbühler (Switzerland))

Dicopper and heteronuclear iron-copper peroxo complex formation: kinetics and thermodynamics

Break

10:50 – 11:10

L60 Luigi Cassella (Italy)

New aspects of the reactivity of tyrosinase

11:10 –  11:30

L61 Per Siegbahn (Sweden)

The catalytic cycle of tyrosinase: peroxide attack on the phenolate ring followed by O-O bond cleavage

11:30 –  11:50

L62 Felix Tuczek (Germany)

New insights into the tyrosinase reaction

11:50 –  12:20

L63 Luigi Bubacco (Italy)

What are the structural features of the active site that define binuclear copper proteins function?

 Break  (10 min)

12:30 –  13:00

L64  to be elected during the congress

Summary and conclusion of the meeting

Lunch

Departure and/or Sight seeing trips: castles, Rhine shipping etc